This is a very long and wavy stage. The route crosses the district of Grosseto, takes in a categorised climb in Scansano, heads towards the upper province of Viterbo, runs along Lake Bolsena and Lake Vico, and takes in the Poggio Nibbio climb, coming from San Martino in Cimino. After a long descent, the route eventually takes a short closing climb, leading to the finish in Sacrofano.
The final kilometres descend at first, and then rise steadily all the way to the finish, with 6/7% gradients. The finish line lies on a 7-m wide asphalt straight.