The route is very long and quite wavy in the first part, where it follows the undulations of the territory of Siena and takes in categorised climbs up Passo del Rospatoio and Passo della Foce. Past Chiusi, the route levels out and rolls along the Trasimeno plain on mainly straight roads (narrow at points), all the way to Foligno.
The final kilometres are quite uncomplicated up to 2,500 m from the finish. From here on, a series of bends leads all the way to the home straight, and the road narrows at points. There is just one last slight bend 500 m before the finish. The home straight is 160-m long, on 7-m wide tarmac.