This challenging stage takes in 6 ascents, including 3 categorised climbs. After the start, the route clears Passo della Somma and descends into Spoleto and climb the Forca di Cerro. The stage course then passes Cerreto di Spoleto and Norcia, takes in a categorised climb up Forca di Ancarano, and finally reaches the Sibylline Mountains. Past Visso, the route clears the Santa Margherita climb, and then ascends to the Sanctuary of Macereto. Upon reaching Polverina, the route continues along wavy and hilly roads leading all the way to Sarnano and to the final Sassotetto climb.
The final kilometres correspond to the closing climb leading to Sassotetto. The gradients are quite steady around 6-7%, peaking out above 10% at points, and long straight stretches alternate with hairpins. The gradient decreases shortly before the finish. The home straight is 100 m long, on 7-m wide tarmac, on a slight incline.