This is the hardest stage with an uphill finish. Starting from Foligno and crossing the Colfiorito pass, a sequence of ascents and descents begins with no flat sections right through to the finish. Three climbs (GPM) are tackled: San Ginesio, Gualdo and Penna San Giovanni. The layout of this stage is extremely articulated both altimetrically and planimetrically and technically challenging both in terms of route and its climbing and descending. The route is mainly on medium-sized roadways with a good to slightly worn surface. The final ascent to the Sassotetto from Sarnano is 14.2km long with 5.8% average gradient, peaking at 12%.
The last kilometers of the stage are the final climb of the Sassotetto. The ascent has fairly constant vertical elevation, between 6 and 7% with some peaks over 10%. Its long straights are interspersed with bends before the gradient softens approaching the finish line. The final straight is 7m wide and 100m long, on a slightly uphill asphalt road.